The will try to beat the for the first time since 2000 when the two teams collide on Sunday Night Football. The 49ers have lost five straight meetings against the Chargers. The average score in those games has been 34-21. San Francisco has not beaten Los Angeles since Week 14 of the 2000 season. This year, the 49ers (4-4) sit in second place in the NFC West while the Chargers (5-3) are in second place in the AFC West.Kickoff is set for 8:20 p.m. ET. San Francisco is a 7.5-point favorite in the Khyri Thomas Jersey latest Chargers vs. 49ers odds from Caesars Sportsbook, while the over/under for total points scored is 45.5. Before making any 49ers vs. Chargers picks or Week 10 predictions, you need to .White, a Fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine's No. 1 expert in against the spread and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He's also gone a whopping 19-7-1 on his last 27 against-the-spread picks involving Atlanta Hawks Hoodie the Chargers, meaning he's well-qualified for this selection.Now, he has locked in on and released his confident SNF picks. . Here are the and trends for Chargers vs. Jeff Teague Jersey Niners: Chargers vs. 49ers spread: San Francisco -7.5Chargers vs. 49ers over/under: 45.5 pointsChargers vs. 49ers money line: San Francisco -350, Los Angeles +275SF: 49ers lead the league in total defense (285.9 yards per game)LAC: RB leads the NFL in touchdowns (10)Chargers vs. 49ers picks: Featured Game | San Francisco 49ers vs. Los Angeles Chargers Moneyline Spread Total SF LAC San Francisco will get a slew of players back from injury for the game. Receivers and , fullback , linebackers and , running back , offensive lineman and defensive end will all be available, according to coach Kyle Shanahan. The return of Samuel means that the 49ers will have both the newly acquired and Samuel in the lineup for the first time.In addition, tight end is playing his best ball of the season. The prolific pa s catcher has had a receiving touchdown in back-to-back games after having zero touchdowns entering Week 7. He also has 80-plus receiving yards in two of his last Steve Smith Jersey three outings. .Los Angeles has one of the NFL's most versatile weapons in Austin Ekeler. The 5-foot-10, 200-pound running back leads the NFL with 10 touchdowns, including six rushing and four receiving. He has rushed for a touchdown NBA Atlanta Hawks Jeresy in five consecutive games, the longest such active streak in the NFL. In addition, the Chargers have dominated the series against the 49ers recently. Los Angeles has won five straight meetings against San Francisco. The average score in those games has been 34-21. .White has analyzed this matchup and while we can tell you he's leaning Under the total, he has discovered a crucial x-factor that makes one side of the spread a must-back. .Who wins 49ers vs. Chargers? And what critical factor makes one side of the spread a must-back? , and find out.
